Sumedha Dahal

Sumedha Dahal

Research Scholar at Memorial Sloan Kettering Cancer Center

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Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions

Published in Molecular Biology of the Cell, 2016

This paper demonstrates that microhomology-mediated end joining is the principal repair pathway for mitochondrial DNA double-strand breaks.

Recommended citation: Tadi, S.K., Sebastian, R., Dahal, S., Babu, R.K., Choudhary, B., & Raghavan, S.C. (2016). "Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions." Molecular Biology of the Cell. 27(2), 223-235.
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DNA double-strand break repair in Penaeus monodon is predominantly dependent on homologous recombination

Published in DNA Research, 2017

This study demonstrates that homologous recombination is the predominant DSB repair pathway in Penaeus monodon.

Recommended citation: Srivastava, S., Dahal, S., Naidu, S.J., Anand, D., Gopalakrishnan, V., et al. (2017). "DNA double-strand break repair in Penaeus monodon is predominantly dependent on homologous recombination." DNA Research. 24(2), 117-128.
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Homologous recombination-mediated repair of DNA double-strand breaks operates in mammalian mitochondria

Published in Cellular and Molecular Life Sciences, 2018

This study provides evidence that homologous recombination operates in mammalian mitochondria for DNA double-strand break repair.

Recommended citation: Dahal, S., Dubey, S., & Raghavan, S.C. (2018). "Homologous recombination-mediated repair of DNA double-strand breaks operates in mammalian mitochondria." Cellular and Molecular Life Sciences. 75, 1641-1655.
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Characterization of G4 DNA formation in mitochondrial DNA and their potential role in mitochondrial genome instability

Published in The FEBS Journal, 2022

This study characterizes G-quadruplex DNA formation in mitochondrial DNA and its role in genome instability.

Recommended citation: Dahal, S., Siddiqua, H., Katapadi, V.K., Iyer, D., & Raghavan, S.C. (2022). "Characterization of G4 DNA formation in mitochondrial DNA and their potential role in mitochondrial genome instability." The FEBS Journal. 289(1), 163-182.
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Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice

Published in Frontiers in Genetics, 2022

This study demonstrates long-term effects of endosulfan exposure on mouse biology and reproduction.

Recommended citation: Sharma, A., Kaninathan, A., Dahal, S., Kumari, S., Choudhary, B., et al. (2022). "Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice." Frontiers in Genetics. 13, 1047746.
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Evaluation of potential role of R-loop and G-quadruplex DNA in the fragility of c-MYC during chromosomal translocation associated with Burkitt’s lymphoma

Published in Journal of Biological Chemistry, 2023

This study evaluates the role of non-B DNA structures in c-MYC fragility during Burkitt’s lymphoma-associated translocations.

Recommended citation: Kumari, N., Das, K., Sharma, S., Dahal, S., Desai, S.S., Roy, U., et al. (2023). "Evaluation of potential role of R-loop and G-quadruplex DNA in the fragility of c-MYC during chromosomal translocation associated with Burkitt's lymphoma." Journal of Biological Chemistry. 299(12).
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Mutations at BCL11B Exon 4 Associated with T Cell Acute Lymphoblastic Leukemia Are Facilitated by AID and Formation of Non-B DNA Conformations

Published in Molecular and Cellular Biology, 2024

This study reveals how AID and non-B DNA structures facilitate mutations in BCL11B associated with T-ALL.

Recommended citation: Roy, U., Sharma, A., Sharma, S., Dahal, S., Kumari, N., Desai, S.S., et al. (2024). "Mutations at BCL11B Exon 4 Associated with T Cell Acute Lymphoblastic Leukemia Are Facilitated by AID and Formation of Non-B DNA Conformations." Molecular and Cellular Biology. 44(12), 590-606.
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Formation of multiple G-quadruplexes contributes toward BCR fragility associated with chronic myelogenous leukemia

Published in Nucleic Acids Research, 2025

This paper demonstrates how G-quadruplex formation contributes to BCR fragility in CML.

Recommended citation: Sharma, S., Thomas, E., Dahal, S., Das, S., Kothari, S., Roy, U., et al. (2025). "Formation of multiple G-quadruplexes contributes toward BCR fragility associated with chronic myelogenous leukemia." Nucleic Acids Research. 53(6).
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